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J Alzheimers Dis 45:395405 Chio A, Cucatto A, Terreni AA, Schiffer D (1998) Reduced glutathione in amyotrophic lateral sclerosis: an open, crossover, randomized trial

Enzalutamide was developed by ligand-based drug design, which relied on the pharmacophores of known drugs, to bind and inhibit the AR with a much improved binding affinity (IC 50 =21 nmol/L, compared with 160 nmol/L for bicalutamide) 162