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Description

NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells

P.StantonC.ShiG.ZhaoJ.et al (2020)

Lancet 341 , 16071610 (1993)

A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) ( E