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Conclusion and perspective Research on lactate metabolism and lactate-derived lactylation, as core drivers of cancer initiation and progression, is gradually changing our traditional perception of lactate as a metabolic waste product. This review systematically examines the basic mechanisms of lactate metabolism, its abnormal manifestations in tumor cells, and the multiple roles of lactate in the TME

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Approximately 40% of individuals with FHI do not have an identifiable mutation in any of the genes known to be associated with FHI

doi: 10.1182/blood-2006-09-044974 127 ChngWJKumarSVanwierSAhmannGPrice-TroskaTHendersonKet al