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10.1007/s11864-024-01250-z 90 LiS.ZengH.FanJ.WangF.XuC.LiY.et al (2023a)

Consequently, most genetic contributions to neurodegenerative phenotypes escape the strict pathogenic/benign dichotomy defined by ACMG, creating a bioinformatic challenge: common variants of small effectand even variants classified as benignmay exert additive influences on phenotype