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These include: Acne (Source 16) Aging (Source 17) Amyotrophic Lateral Sclerosis, ALS (Source 18) Celiac disease (Source 19) Chronic Fatigue Syndrome (Source 13) Eczema (Source 20) Fatty liver disease (Source 21) Inflammatory Bowel Disease Crohns and Ulcerative Colitis (Source 22) Migraines (Source 23) Multiple Sclerosis (Source 2) Non-Celiac Gluten Sensitivity (Source 24) Psoriasis (Source 25) Rheumatoid Arthritis (Source 2) Rosacea (Source 16) Sleep apnea (Source 26) Small Intestine Bacterial Overgrowth, SIBO (Source 27) Type 1 Diabetes (Source 2) Type 2 Diabetes (Source 15) There are likely more, but you get the point

Most of what we know to date comes from a mix of preclinical research and the biological mechanisms each therapy targets

Shen Y, Stanislauskas M, Li G, Zheng D, Liu L

and [4] worsening of the symptoms in the evening or during the night