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To allow the transport of essential molecules and restrict harmful substances, the intracellular signaling transduction system and a number of extracellular stimuli such as cytokines, small GTPases, and post-translational modifications dynamically modulate the tight junction protein complexes

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While no apparent changes were observed in astrocyte-specific features, such as cellular morphology, marker gene expression, and immune competence, BD iAstrocytes displayed different endophenotypes related to cellular metabolism (Supplementary Fig

Sleep deprivation and aging are known to upregulate histone deacetylases, which remove acetyl groups from histone proteins, leading to chromatin condensation and suppressed expression of genes critical for long-term potentiation and synaptic plasticity (Wong et al., 2020)