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Improvements were also observed in gastrointestinal symptoms and behavioral problems after the intervention [52]

A systematic evaluation of peripheral cytokines (e.g., via multiplex Luminex assays) will be conducted in follow-up studies to map gut-derived immune signals to CNS pathology

These two types of Gpx operate with distinctly different kinetics

Copper-dependent generation of Cu + and ROS within mitochondria rapidly blocks Fe-S assembly, disabling TCA cycle enzymes and precipitating cuproptosis while simultaneously derepressing IRP2 to raise labile iron, thereby amplifying lipid peroxidation and ferroptotic death (Lin et al