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piezogenic papules) Edema in the legs in the absence of cardiac failure Mild proximal and distal muscle weakness Axonal polyneuropathy Atrophy of muscles in hands and feet Acrogeric hands, mallet finger(s), clinodactyly, brachydactyly Vaginal/uterus/rectal prolapse Dermatosparaxis EDS (dEDS) If a person meets the diagnostic criteria for dEDS, genetic testing should be done to confirm the diagnosis

The amount of water consumption also tends to affect BAC levels

A meta-analysis showed that intravitreal administration of ranibizumab was associated with systemic vascular adverse events, including embolic eventsstroke and myocardial infarction (Sultana and Scondotto 2020)

There is a second layer worth untangling: NAD+ itself versus NAD precursors