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In doxorubicin-resistant human uterine sarcoma (MES-SA/Dx5), apigenin reduces intracellular glutathione (GSH) levels by inhibiting ATP-binding cassette subfamily B member 1 (ABCB1) [60], while in prostate cancer, it reverses doxorubicin resistance by down-regulating ABCB1 protein expression [61]

Moreover, a randomized clinical trial in patients with advanced pancreatic carcinoma demonstrates that combination of the anti-IGF-IR mAb MK-0646 with gemcitabine is tolerable and associated with improvement in overall survival but not progression-free survival as compared with gemcitabine plus erlotinib [151]

Despite their susceptibility to reducing conditions, including enzymes like reductases, 67,68 disulfide-bridged peptides have received widespread attention due to their diverse bioactivity, ability for cell penetration, proteolytic stability and resilience to some harsh conditions such as high temperature, acidic pH and chaotropic agents