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The main purpose of Modifier 25 is Significant, separately identifiable E/M service by the same physician on the same day of the procedure. For example, a patient comes in with a sore throat and during the exam, the provider decides to give an intramuscular steroid shot

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Even so, the scientific evidence is still thin and the effect of B12 cream remains under question by many dermatologists, even though individual patients have reported successful results

Unfortunately, with other forms of treatment such as medications and injections, this isnt always the case