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First, we systematically analyzed the ESCC cancer tissues and distant non-cancerous mucosa, as well as preoperative serum and urine samples from the same ESCC patients, to observe the common malignancy-related metabolic profiles in three samples

Toward the rational control of transsulfuration

Sections were then washed and mounted with VECTASHIELD HardSet aqueous mountant (Vector Laboratories, Burlingame, CA, USA) and viewed using an Olympus FV1000 confocal laser scanning microscope (Olympus Corporation, Tokyo, Japan)

Meanwhile, the ratio of GSR to GPX4 at the protein level was decreased in the A2ARi-treated group compared with the control group (Figure 3I), indicating that the GSSG accumulation upon A2ARi treatment is caused likely by an impaired capacity to recycle GSSG back to GSH