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Notably, in the subgroup of patients naive to prior mTORC1 inhibitor therapy, the ORR reached 22%, significantly superior to that of conventional rapalogs (ORR: 1%-8.6%), with the longest partial response duration exceeding 16 months (241)

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Once release, alarmins can activate type 2 innate lymphoid cells (ILC2), Mast cells and antigens-presenting cells (APCs)

Taking into account that the main substrate for SOD1 and SOD3 is the superoxide anion [63], we also induced oxidative stress using xanthine oxidase and menadione, compounds known to be superoxide-generating agents