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3.3 Pyroptosis pathway Depending on whether pyroptosis requires caspase-1 activation, it can be divided into the classical and non-classical inflammasome pathways ( Figure 5 )

This is believed to lead to activation of the MPTP due to oxidative stress and depletion of ATP, resulting in apoptosis or necrosis, dependent on the severity of mitochondrial dysfunction and the degree of ATP loss (Visentin et al., 2020

In another study, a gene called GhMKK3 helps in regulating drought tolerance

However, aggregated virions may still attach to some extent to target cells depending upon the nAb and assay conditions, and aggregation may affect a step downstream from viral attachment such as fusion or viral egress from infected cells (see below)