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Preclinical and observational data suggest that side effects primarily depend on dosage, frequency, and individual metabolic response

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The terms are often used interchangeably in supplement and wellness discussions

In vivo experiments demonstrated the protective effect of EE treatment against accelerated bone loss, where reduced serum levels of TRAP, CTX, TNF, LPS, and IL-6 and increased serum levels of P1NP were observed in EE-treated mice