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Typically, dietary phenolic substances are extensively metabolized, e.g., by gut bacteria as well as by phase I and phase II reactions in enterocytes and hepatocytes ( metabolite have been investigated in erythrocytes employing a metabolomic approach ( While in vitro experiments yield detailed information on single aspects, in vivo studies with human volunteers or patients allow for the determination of typical pharmacokinetic parameters, such as maximum concentrations in serum or plasma (c max ), time of peak concentrations (t max ), area under the curve (AUC), half-live (t) and other elimination characteristics

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CAFs significantly increase the catabolism of BCAAs and the secretion of BCKAs in the nutrient-poor tumor microenvironment (TME)

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