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Murphy, S

For each variant of porphyria, the defective enzyme in the process is as follows: AIP: Porphobilinogen deaminase (or hydroxymethylbilane synthase) VP: Protoporphyrinogen oxidase HCP: Coproporphyrinogen oxidase ADP: Delta-ALA dehydratase PCT and HEP: Uroporphyrinogen decarboxylase EPP: Ferrochelatase CEP: Uroporphyrinogen III cosynthase XLP: Erythroid-specific delta-aminolevulinic synthase-2 Porphyria Triggers Porphyria is typically triggered by: Certain medicines, such as hormonal b irth control, sulfa antibiotics, barbiturates, anesthetics, and seizure medicines Cyclic progesterone hormone activity in AFAB people Drinking alcohol, especially binge drinking (consuming more than four to five drinks in a 2-hour period) or heavy drinking (consuming more than 7-14 drinks in a week) Smoking Exposure to sunlight Low intake of carbohydrates, perhaps due to fasting, dieting, illness, or weight loss surgery Getting an infection or another illness Emotional or physical stress PCT can also be triggered by: Another genetic condition called hemochromatosis that causes iron to build up in your body Infection with a virus, such as hepatitis C and HIV Symptoms of Porphyria One of the ways experts use to classify porphyria is by the main symptoms each variant causes

The mechanism underlying the negative correlation between serum iron and gallstone formation remains unclear