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Retrospective analysis of HLA class II-restricted neoantigen peptide-pulsed dendritic cell vaccine for breast cancer

For most patients with vitamin B12 deficiency, high-dose oral supplements are as effective as intramuscular injections at raising serum B12 levels and resolving symptoms

The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models