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Manipulation of intracellular NAD + levels via supplementation with NAD + precursors and altering NAD + -biosynthetic or-consuming pathways can release immunomodulatory properties in various T cell-mediated inflammatory disorders

Phytomedicine 23(12):14011408 Sun SC (2011) Non-canonical NF-B signaling pathway

Consider these evidence-based dietary strategies: Eat small, frequent, low-fat meals that are easier to digest Limit sugar alcohols (sorbitol, mannitol, xylitol) found in sugar-free products, which have known laxative effects Gradually increase soluble fiber through foods like oatmeal and psyllium supplements, which can help bulk stools Avoid excessive insoluble fiber from raw vegetables and whole grains during acute episodes Stay adequately hydrated with water and electrolyte-containing beverages to prevent dehydration Avoid spicy, greasy, or very high-fiber foods during episodes of diarrhea Medication dosing may require adjustment

Given the consequences of genotoxic stress, counteracting DNA damage in the body may take the form of firstly, DNA repair mechanisms being enhanced, or secondly, preventing DNA damage through strengthening the integrity of the epidermal barrier between UVR and our UV-labile molecular components