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Chronic Wounds Pose a Major Challenge in Healthcare Chronic wounds represent a growing challenge for modern healthcare and constitute a major public health concern due to their significant impact on patients quality of life

However, there are currently no imaging findings considered specific for Lyme neuroborreliosis, and significant overlap exists with other neurologic conditions, particularly multiple sclerosis (120)

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Mechanism involves NO system modulation (homeostatic regulationupregulating when deficient, moderating when excessive), VEGF/VEGFR2 upregulation for angiogenesis, FAK-paxillin pathway activation for cell migration (40% increase per Chang et al.), and EGR-1 transcription factor upregulation for growth factor sensitivity