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Keywords: androgenetic alopecia, Erzhiwan, JNK, p38 MAPK, oxidative stress, SIRT1 Graphical Abstract: Introduction Androgenetic alopecia (AGA) is a multifactorial type of hair loss, characterized by hair follicles miniaturization, in which highly expressed 5- reductase and excessive sensitivity of the androgen receptor (AR) are the two critical events