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While B12 can be found in foods such as meat, fish, and dairy products, some individuals may not get enough through their diet

Its multifunctional properties make it popular for skin healing, anti-aging, and potential hair restoration

In a study investigating obese patients with nonalcoholic steatohepatitis (NASH) the ratio of L/M excreted was similar to healthy controls suggesting no change in intestinal permeability [213]

Acknowledgements The authors would like to thank every researcher that contributed to the understanding of the close relationship between the IGF-1 deficiency and the Metabolic Syndrome establishment