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2013;8(9):e71529

Dl-3- n -butylphthalide enhances collateral circulation by promoting endothelial nitric oxide synthase activity and activates neurotrophic signaling pathways such as brain-derived neurotrophic factor/tropomyosin receptor kinase B (TrkB) and calcitonin gene-related peptide (CGRP), thereby improving synaptic plasticity and cognitive recovery 17 (Fig