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that is, oxidative signals derived from ZON ( c , ROS production, induction of caspase-3/8, and ER stress in human leukemia cells (Table 2) (72)

J Clin Oncol 27: E20-E21, 2009

Furthermore, increased expression of heme oxygenase-1 (HO-1) in microglia and loss of copper chaperone protein (CP) activity in astrocytes contribute to iron deposition in the central nervous system (CNS) and neuronal death [182]