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First-pass metabolism occurs when a compound is absorbed from the gut and passes through the liver, where it can be partially broken down before reaching the rest of the body

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Mazdutide , cagrilintide , and orforglipron (an oral GLP-1 agonist) represent additional next-generation options that could offer different benefit-risk profiles for endometriosis patients

We are currently amid an evolving revolution in obesity pharmacotherapy, with increasingly efficacious anti-obesity medicines (AOMs), incorporating uni-, bi- and trimolecular incretin receptor agonists [8, 9]