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Preliminary results of the neratinib arm in the individualized screening trial of innovative glioblastoma therapy (INSIGhT): a phase II platform trial using Bayesian adaptive randomization

Although GIP receptor activation may exert anti-emetic effects through brainstem modulation, these effects appear insufficient to completely counterbalance GLP-1 mediated emesis during early treatment and dose escalation ( In contrast, glucagon receptor activation is independently associated with nausea and vomiting through both central and peripheral mechanisms, including effects on gastric motility and autonomic signaling