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Consequently, in disease states marked by intrinsic energy insufficiency, such as neurodegeneration [42] , it may be the failure of metabolic resilience, rather than the presence of excess free iron, which acts as the primary driver of ferroptosis

Those that are symptomatic generally have persistence in temperature and leukocytosis suggesting the possibility of infected necrosis, nausea or vomiting indicating compression of stomach or duodenum, or abdominal pain especially after eating as a result of greater pressure within organized necrosis caused by extravasation of fluid from residual normal pancreatic parenchyma in the remnant tail of the pancreas