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Results showed superiority of both levodopa dose reduction regimens with opicapone adjunct in terms of significant reductions of OFF-time and increases in ON-time vs the original 500 mg/day as well as significant increases in the minimum level of levodopa plasma concentrations and area under the curve (AUC) values

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This method demonstrated successful GBM cell movement, hydrogel penetration, and significant cytotoxicity, highlighting its potential for targeted GBM therapy [144]