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Armstrong MJ, Hull D, Guo K, Barton D, Hazlehurst JM, Gathercole LL, et al

Finally, the indiscriminate use of Se supplements should be taken with caution given its possible toxic effects that occur when exceeding its recommended consumption limits

[171] reported that APOE*3Leiden.CETP mice exposed to alternating lightdark cycleinduced circadian disruption presented a notable increase in atherosclerosis, with a nearly twofold increase in the size and severity of lesions [171]