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Description

As extensively researched, the primary adaptive responses athletes seek during altitude sojourns include primarily the erythropoietin (EPO)-driven increase in red blood cells (or hemoglobin mass (HBmass) [1,2,3,4,5])

Ibrahim J, Nguyen AH, Rehman A, Ochi A, Jamal M, Graffeo CS

Hypoxia resulting from lung injury triggers hypoxia-inducible factor-1 (HIF-1), which upregulates endothelin-1, further constricting pulmonary vessels and stressing the RV