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It induces inflammation and oxidative damage in the brain, which can be a significant factor in neurodegenerative diseases (Coelho et al

Toe Taps Strengthen shin muscles to support the tibia

The elevated glycolytic flux and the decrease in pentose-phosphate flux suggest that Pink1-deficient neurons suffer a glucose metabolism reprogramming from mitochondrial oxidative to glycolytic metabolism compromising the PPP (Requejo-Aguilar et al., 2014)