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Classification (By Generation) 1st Generation Examples: Cefazolin Cephalexin Coverage: Good Gram-positive bacteria Limited Gram-negative coverage Common uses: Skin and soft tissue infections Surgical prophylaxis 2nd Generation Examples: Cefuroxime Cefaclor Coverage: More Gram-negative than 1st generation Common uses: Respiratory tract infections Otitis media Community-acquired pneumonia 3rd Generation Examples: Ceftriaxone Ceftazidime Cefotaxime Coverage: Broad Gram-negative coverage Good CNS penetration Special note: Ceftazidime covers Pseudomonas Common uses: Severe infections Meningitis Sepsis Typhoid fever 4th Generation Example: Cefepime Coverage: Strong Gram-positive and Gram-negative coverage Covers Pseudomonas Uses: Hospital-acquired infections 5th Generation Example: Ceftaroline Coverage: Only cephalosporin effective against MRSA Limited Gram-negative coverage 3

Also, TCAs modulate activity at postsynaptic cholinergic, muscarinic, and histamine receptors