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The evidence that does exist belongs to the parent compounds and must be tiered honestly: Semax: registered in Russia (a national approval, not FDA/EMA) for ischemic stroke and related indications, supported mainly by Russian clinical studies that are frequently non-randomized, open-label, or small, plus a substantial preclinical literature

This family of compounds represents a new class of drugs with lead candidates that are orally active, penetrate the BBB sufficiently to reach therapeutic concentrations, and reverse memory deficits seen in animal models of dementia

Health 19 , 1131 (2014)

Current Evidence Gaps No direct head-to-head randomized controlled trials comparing Retatrutide and Cagrilintide monotherapy exist in the published literature