![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase](https://ars.els-cdn.com/content/image/1-s2.0-S0223523421002087-ga1.jpg)
interaction of chloroacetamide electrophiles with cellular glutathion
interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase
Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis induced tumor cell death ScienceDirect Development of a Highly Selective Ferroptosis Inducer Targeting GPX4 with 2 Ethynylthiazole 4 carboxamide as Electrophilic Warhead Journal of Medicinal Chemistry Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology New mechanistic insights into halogen dependent cytotoxic pattern of monohaloacetamide disinfection byproducts ScienceDirect
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![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase](https://ars.els-cdn.com/content/image/1-s2.0-S0223523425008724-ga1.jpg)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase](https://pubs.acs.org/cms/10.1021/acs.jmedchem.4c02530/asset/images/medium/jm4c02530_0013.gif)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41556-026-01921-z/MediaObjects/41556_2026_1921_Fig1_HTML.png)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase](https://ars.els-cdn.com/content/image/1-s2.0-S0304389423024160-ga1.jpg)