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Validation of the metabolic capabilities of phase specific AM GSM models The E-flux models were next validated to ensure their ability to simulate biologically significant processes by reproducing important metabolite production rates and characteristic behavior as reported in literature

pinnata extracts significantly reduced nitric oxide (NO) production ( P = 0.00003), enhanced uric acid uptake ( P = 0.00003), and increased SOD activity (MEPP), while having no significant effect on glutathione (GSH) content in treated cells

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Due to the short-term exposure to NAs (24 h) in the present study, the in vitro alkaline comet assay likely detected mainly DNA N -alkylation damage and its subsequent repair by base excision repair (BER)