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doi: 10.1038/nrurol.2016.23 [DOI] [PubMed] [Google Scholar] 26

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More recent studies in AD mouse models have indicated that KD improves cognitive function, alleviates neuroinflammation, reduces A plaque deposition, and decreases microglial activation

These active components help reduce abnormal -syn aggregation, block its neurotoxic effects, inhibit the apoptosis of dopaminergic neurons in the substantia nigra, regulate microglial activation, reduce the release of pro-inflammatory factors such as TNF- and IL-1, enhance antioxidant defense systems (e.g., by upregulating the Nrf2/HO-1 pathway) to mitigate oxidative stress damage, and promote neuroregeneration and synaptic repair