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It occurs at the level of gene transcription [11, 12], epigenetic regulation [13,14,15], post-translational modifications of core and accessory cell death machinery components [16,17,18], organelle-specific mechanisms [19], and organelle crosstalk [20, 21]

Additionally, ALS patient-derived induced astrocytes (iAstrocytes) were neurotoxic toward mouse motor neurons and their expression levels of disease-associated markers, including GFAP, CX43 and Ki-67, and miRNA profiles varied among patients, suggesting the astrocytes heterogeneity in ALS (Gomes et al., 2022)

Fluorescence images were obtained using confocal laser scanning microscopy [LSM800

Do not try to increase the dosage on your own, as it can result in serious side effects