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In this context, natural products possessing antioxidants and anti-inflammatory properties have gained attention as a potential alternative therapeutic approach to treating glaucoma [136]

The UDP glycosyltransferase superfamily: recommended nomenclature update based on evolutionary divergence

When folate levels are significantly decreased, the 5-MTHF metabolic pathway is blocked and the SAMe/SAH ratio is down-regulated, which inhibits methyltransferase activity and disrupts DNA methylation homeostasis thus leading to delayed closure of the neural tube, and ultimately to the formation of neural tube defects (NTDs) (105)