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Certain inflammation-related factors, such as lipopolysaccharides, can activate Piezo1 channels, triggering both the influx of calcium ions and also the release of intracellular stores of calcium ions, leading to oxidative cellular damage and disintegration of the CNS cytoskeleton, manifesting as irreversible neurodegeneration (Lee et al., 2021)

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Those who are more likely suffering from this deficiency include anemics, vegans, vegetarians, people with multiple food allergies, and people who are over 50 years old