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12/15-LOX: 12/15-lipoxygenase 13-( S )-HODE: 13-( S )-hydroxyoctadecadienoic acid 15-HETE: 15-hydroxyeicosatetraenoic acid AA: arachidonic acid AHR: airway hyperresponsiveness ALOX15: arachidonic acid 15-lipoxygenase ATP: adenosine triphosphate COX: cytochrome c oxidase ETC: electron transport chain H 2 O 2 : hydrogen peroxide IgE: immunoglobulin E IL-4: interleukin-4 IL-4R: interleukin 4 receptor O 2 : superoxide anion OE: overexpressed OVA: ovalbumin ROS: reactive oxygen species SPMs: specialized pro-resolving mediators STAT-6: signal transducer and activator of transcription-6 Th2: T helper 2 VITs: vitamins MVG and AB equally contributed to: Writingoriginal draft, Writingreview & editing

Synthesis of ROS-sensitive polymers (P1) To a solution of 1 h,1 h,10 h,10h-perfluoro-1,10-decanediol (0.62 g, 1.35 mmol) and ROS sensitive molecular (2,2-(propane-2,2-diylbis(sulfanediyl))bis(ehan-1-ol)) (0.26 g, 1.35 mmol) in anhydrous DMF (5 mL), 1,2,4,5-cyclohexanetetracarboxylic dianhydride (0.63 g, 2.83 mmol) was quickly added

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