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Polypeptides of the invention which comprise a signal sequence have an N-terminus beginning within 5 residues (i.e., + or 5 residues, or preferably at the 5, 4, 3, 2, 1, +1, +2, +3, +4, or +5 residue) of the predicted cleavage point

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Seddon et al

Importantly, SGLT1 knockdown further enhanced the regulatory effects of XBP on myocardial energy metabolism, whereas SGLT1 overexpression reversed its cardioprotective effects, confirming that SGLT1 is a key molecular target in the improvement of XBP-mediated FAO