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Recently, Lin and colleagues showed that vitamin E could reverse the effect of the cytotoxic drug bioallethrin on human glioblastoma cells by inhibiting OS and endorsing endogenous redox defense pathways, thus obstructing the chemotherapeutic effects of the drug [105]

Intravenous (IV) fluid drips deliver saline solution through a small catheter and tubing directly into the bloodstream

ROS scavengers like Nacetylcysteine and Methotrexate, which inhibit NET formation by reducing ROS formation, have shown remarkable therapy benefits in some clinical or preclinical trials (210, 211)

The pathophysiology of IC/BPS is poorly understood, and theories include chronic inflammation, autoimmune dysregulation, bacterial cystitis, urothelial dysfunction, deficiency of the glycosaminoglycan (GAG) barrier and urine cytotoxicity