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Tissue Res

The PPARGC1A was found to have a binding affinity of 9.55 kcal/mol with 5 hydrogen bond interactions with amino acids, GLU A:301, ARG A:372, LEU A:305, LYS A:304, ARG A:419, along with unfavourable donor interactions with amino acids GLU A:331, PRO A:302, LYS A:426 with hydroxy groups (aromatic) of the compound EGCG

Bokaie M, Farajkhoda T, Enjezab B, Khoshbin A, Karimi-Zarchi M

The adrenergic modulation hypothesis Graf and Kastins review raised the possibility that DSIP acts by modulating adrenergic transmission rather than by any direct hypnotic action