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Importantly, inhibition of TF-induced coagulation activation reduces microvascular stasis and lung vaso-occlusion in sickle mice (140)

Huang et al., 2022) or sarcopenia (Kim et al., 2023

Rats are also physiologically, genetically and morphologically closer to humans, with six tau isoforms, similar ApoE properties, similar immune system and a wider behavioral display, compared to mice 61