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Plasma concentrations decline with age - from approximately 200 ng/mL at age 20 to under 80 ng/mL by age 60

International journal of molecular sciences, 15(3), 48374855

Higher water volumes reduce concentration but require a larger draw

A 2024 pharmaceutical review in Pharmaceuticals raised tumorigenesis as a theoretical risk, though a 2025 response published in the same journal directly countered the concerns