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Description

Nasal spray formulations that deliver tirzepatide through the nasal mucosa

13 and 14 in Supplementary Note)

Type I cadherins include E-cadherin (Cdh1), N-cadherin (Cdh2), P-cadherin (Cdh3), and R-cadherin (Cdh4)

After 1 year of follow-up post re-treatment, recurrence of symptoms was observed among the participants without re-treatment, whereas the clinical manifestations of retreated patients were as that in the initial treatment