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Biochem Biophys Res Commun 2017;490:5529

These evolutionary studies reveal that fewer clones of cancer cells from the primary tumor site can form metastases in distant organs compared to TDLNs, which might be attributed to the different selective pressures and microenvironments in these organs, such as the varying metabolites in distant organs (161, 162)

Ferroptosis is a type of regulated cell death (RCD) that occurs due to the iron-dependent accumulation of lipid ROS and is characterized by distinct morphological, biochemical, and genetic features that differentiate it from other RCD types, which include apoptosis, various necrosis types, and autophagy (12, 13)