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In fact, stimulants and anti-depression medications that improve focus or concentration work by increasing the production of these neurotransmitters, particularly norepinephrine

Furthermore, the lack of B12 allows toxic byproducts like hydrogen sulfide and excess nitric oxide to accumulate in the brain

NNMT inhibition works by blocking an enzyme, not by overstimulating a receptor, so the usual receptors desensitize and stop responding pattern that drives cycling for a lot of peptides doesnt obviously apply here