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These are especially prevalent in astrocytic processes surrounding blood vessels and play a critical role in fluid homeostasis (Benarroch, Astrocytic end-feet come into close contact with the endothelial cells of the vasculature and form part of the blood-brain barrier (Abbott et al., 2010)

for instance, it activates the TLR4/NF-B/miR-21 axis to downregulate RASA1 and drive tumor growth (Yang et al., 2017), and its adhesin RadD binds to CD147 to activate the PI3K-AKT-NF-B-MMP9 pathway (Wang et al., 2024) and confers resistance to 5-fluorouracil by upregulating BIRC3 through TLR4/NF-B signaling (Zhang et al., 2019)

Circ Cardiovasc Interv

10.1038/jcbfm.2015.115 J