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Macrophage apoE stimulates phospholipid and cholesterol efflux via ABCA1, and the apoE particles formed then promote cholesterol efflux through ABCG1, SR-BI, and aqueous diffusion (104,109-111)

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Firstly, the E1 subunit catalyzes the decarboxylation of the BCKA, releasing CO 2 and the corresponding branched-chain acyl intermediate