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In three of these trials, an increased risk of hemorrhagic stroke and heart failure was observed in male smokers and men with a history of cardiovascular disease, respectively

doi: 10.1016/j.cell.2013.12.016 46 DevillardE.McIntoshF

Compliance, described as taking at least 90% of the supplements, was assessed by the returned pill count ( Physical activity, dietary intake, and anthropometric assessments Physical activity level (PAL) and dietary intake were evaluated at three time points: weeks 1 (baseline), 4, and 8

Dosage should be determined through individual clinical assessment with a qualified healthcare provider